Palmitoylethanolamide Supplement: How It Works And What Are The Benefits?

Several supplements in the market help in providing the body with the needed dietary requirements. One such up and coming supplement is of palmitoylethanolamide. F late under several research papers, it is found out that palmitoylethanolamide supplement is effective in managing pain and also in making more healthy due to its fatty benefits.

About palmitoylethanolamide

Palmitoylethanolamide is a compound that is produced in the body of humans and is responsible for pain management. It has a mechanism that reduces the inflammation in the body and thus helps in reducing the pain. It helps increase the bliss fatty acids in the body and is also categorized as neuroactive fatty acids. It is found in animals and plants as well. It can be ingested either as a supplement of palmitoylethanolamide or in the raw form eating various PEA rich food like peanuts, soybeans, alfalfa, soy lecithin, egg yolk, etc.

Working of palmitoylethanolamide

The entire mechanism and working of palmitoylethanolamide are based on its capability to reduce pain and increase calm in case of inflammation. To reduce pain and inflammation, palmitoylethanolamide works on the PPAR alpha by activating it. PPAR alpha is a protein that helps in reducing the inflammatory genes and also lower the production of substances that cause pain in the blood. The PPAR alpha activation helps in boosting energy, reducing inflammation, and also helps in burning fat.

Also, palmitoylethanolamide helps in increasing the calming sense in the body, especially during the situation of pain and inflammation. The FAAH bliss gene is responsible for breaking the anandamide in the body, which in turn causes one to get agitated and restless. However, palmitoylethanolamide lower the FAAH activity, which in turn increases the amount of anandamide, giving a sense of relaxation that helps in combating pain effectively.


PEA is something that can be gained from natural foods, but in case of lack of a balanced diet, palmitoylethanolamide supplement and Pyrroloquinoline Quinone can be highly effective. Some of the basic advantages of palmitoylethanolamide supplement are:

  • Pain management

One of the significant benefits that one can get with increased PEA concentration is pain relief. Asmentioned above, it can help in increasing energy and reduce inflammation-causing agents. This helps in causing less pain in the body caused due to any particular reason.

  • Eye health

Palmitoylethanolamide supplements help in maintaining eye health as it keeps the eye nerves healthy, thus supporting the good vision. Also, it is seen in patients that PEA can help in lowering the eye pressure and increases the vision clarity over time.

Palmitoylethanolamide Supplement: How It Works And What Are The Benefits?

  • Brain health

As the PEA keeps the capability to maintain good nerve health, it is quite fair to say that is can help in reducing brain damage. Under various research, it has been found that PEA can help in treating neurodegenerative disease and reduce brain cell inflammation.

  • Multiple sclerosis

Multiple sclerosis is a major autoimmune disease and has strong treatment procedures. First-line therapy can have strong side effects like pain and inflammation. PEA can help in alleviating these problems, thus helping in better treatment success rates.